Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
40 mg
44%
Thiamin (as thiamin HCl)
60 mg
5000%
Riboflavin (as riboflavin and riboflavin-5-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
50 mg
313%
Vitamin B6 (from pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2941%
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41677%
Biotin
600 mcg
2000%
Pantothenic Acid (as d-calcium pantothenate)
100 mg
2000%
Top Medical Research Studies
9
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
Read More
9
We looked into whether vitamin B-6 could help prevent heart failure with preserved ejection fraction (HFpEF) in a mouse model. By using a high-fat diet and other supplements, we created conditions for HFpEF and tested the effects of vitamin B-6 on cardiac function.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
Read More
8
We explored the impact of long-term vitamin B1 (VB1) maintenance on heart failure (HF) outcomes through a study involving 88 patients. These patients were divided into three groups based on their VB1 levels: a control group with normal levels, a group receiving short-term supplementation, and a group focused on long-term maintenance of normal levels.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
Read More
Most Useful Reviews
9
Excellent composition
1 people found this helpful
This brand offers a high-quality B-complex with robust natural ingredients. It's crucial for the nervous system, detoxification, and supporting heart health; it's especially necessary for children with ASD, pregnant women, and those at risk of heart disease. It’s an effective choice; I highly recommend it!
Read More
7.5
Emotional stability
16 people found this helpful
This complex has an excellent formulation of B vitamins in appropriate dosages. My husband and I took it during a stressful three-month period alongside inositol and magnesium. Gradually, it became easier to manage stress, thoughts became less overwhelming, and I regained clarity in decision-making, while life regained its vibrancy. We concluded that it’s essential to take it during such times to prevent psychosomatic consequences of stress.
Read More
7.5
Overall health support
3 people found this helpful
Doctor's Best All-Active B-Complex offers eight vital B vitamins in a more easily absorbed formula. It aids cell metabolism, DNA synthesis, and protects the immune system and heart health. Quatrefolic® ensures better bioavailability of folate, essential for DNA synthesis and cell division, alongside supporting energy production and overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
- All Researches
9
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
Read More
9
We looked into whether vitamin B-6 could help prevent heart failure with preserved ejection fraction (HFpEF) in a mouse model. By using a high-fat diet and other supplements, we created conditions for HFpEF and tested the effects of vitamin B-6 on cardiac function.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
Read More
8
We investigated how a specific gene variation (MTHFR C677T) influences the outcome for patients with coronary heart disease and hypertension receiving folic acid and enalapril.
Over 540 patients were studied, dividing them into groups that received folic acid or standard treatment.
Our results revealed that patients who took folic acid had better outcomes, including lower rates of cardiovascular events, compared to those who did not. This indicates that folic acid supplementation may enhance treatment success for these high-risk patients.
Over 540 patients were studied, dividing them into groups that received folic acid or standard treatment.
Our results revealed that patients who took folic acid had better outcomes, including lower rates of cardiovascular events, compared to those who did not. This indicates that folic acid supplementation may enhance treatment success for these high-risk patients.
Read More
8
In our exploration of TANGO2-deficiency disorder, we found that cardiac arrhythmias linked to this genetic condition are often resistant to standard treatments.
Using innovative patient-derived stem cell models, we identified that high doses of folate (vitamin B9) can significantly reduce arrhythmias.
Clinical data also indicated that multivitamin and B complex intake may lower the risk of serious heart issues in affected individuals.
This suggests that B vitamins might offer a life-saving strategy for managing dangerous cardiac events in patients with this disorder.
Using innovative patient-derived stem cell models, we identified that high doses of folate (vitamin B9) can significantly reduce arrhythmias.
Clinical data also indicated that multivitamin and B complex intake may lower the risk of serious heart issues in affected individuals.
This suggests that B vitamins might offer a life-saving strategy for managing dangerous cardiac events in patients with this disorder.
Read More
8
We explored the impact of long-term vitamin B1 (VB1) maintenance on heart failure (HF) outcomes through a study involving 88 patients. These patients were divided into three groups based on their VB1 levels: a control group with normal levels, a group receiving short-term supplementation, and a group focused on long-term maintenance of normal levels.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Excellent composition
1 people found this helpful
This brand offers a high-quality B-complex with robust natural ingredients. It's crucial for the nervous system, detoxification, and supporting heart health; it's especially necessary for children with ASD, pregnant women, and those at risk of heart disease. It’s an effective choice; I highly recommend it!
Read More
7.5
Emotional stability
16 people found this helpful
This complex has an excellent formulation of B vitamins in appropriate dosages. My husband and I took it during a stressful three-month period alongside inositol and magnesium. Gradually, it became easier to manage stress, thoughts became less overwhelming, and I regained clarity in decision-making, while life regained its vibrancy. We concluded that it’s essential to take it during such times to prevent psychosomatic consequences of stress.
Read More
7.5
Overall health support
3 people found this helpful
Doctor's Best All-Active B-Complex offers eight vital B vitamins in a more easily absorbed formula. It aids cell metabolism, DNA synthesis, and protects the immune system and heart health. Quatrefolic® ensures better bioavailability of folate, essential for DNA synthesis and cell division, alongside supporting energy production and overall health.
Read More
7.5
B12 for health
This vitamin has a strong formulation, including folate, vital for DNA synthesis and emotional health, as well as for heart disease prevention.
Read More
7.5
Improved wellbeing
This complex of B vitamins is essential for numerous bodily functions, notably the brain, nervous system, and heart. B12 fosters DNA production, while B6 and B1 contribute to heart and blood vessel health. Folic acid and B6 also enhance emotional wellbeing by boosting serotonin production. This complex aids in filling vitamin deficiencies and enhancing overall health.
Read More
Frequently Asked Questions
7.5
Emotional stability
16 people found this helpful
This complex has an excellent formulation of B vitamins in appropriate dosages. My husband and I took it during a stressful three-month period alongside inositol and magnesium. Gradually, it became easier to manage stress, thoughts became less overwhelming, and I regained clarity in decision-making, while life regained its vibrancy. We concluded that it’s essential to take it during such times to prevent psychosomatic consequences of stress.
8
Supports heart health
1 people found this helpful
This vitamin complex provides all B vitamins, supporting heart and blood vessel health, normalising sleep, and metabolism. It’s in methyl form for better absorption, and I can feel the positive effects. The quality is excellent, and the packaging is conveniently hermetically sealed.
7.5
Vital energy boost
This really works for providing vital energy, ensuring a healthy heart with a suitable amount of quality ingredients.
7.5
Heart health support
5 people found this helpful
I appreciate this B complex as it contains methylcobalamin B12 and MTHF, which is beneficial for heart health. I believe it’s effective and can recommend it.
7.5
Enhanced energy
This vitamin complex delivers all B vitamins, promoting heart and blood vessel health, improving sleep and metabolism. The methyl form enables effective absorption, and I've noticed a boost in energy. The quality is top-notch, with convenient packaging that lasts a long time.
2
Caution advised
This supplement prompted new hair growth for me, though I had no previous issues. I gave it four stars as I experienced discomfort in my heart area after starting it, leading me to stop. It’s essential to consult nutritionists or doctors before beginning any vitamin regimen.
7.5
B12 for health
This vitamin has a strong formulation, including folate, vital for DNA synthesis and emotional health, as well as for heart disease prevention.
7.5
Improved wellbeing
This complex of B vitamins is essential for numerous bodily functions, notably the brain, nervous system, and heart. B12 fosters DNA production, while B6 and B1 contribute to heart and blood vessel health. Folic acid and B6 also enhance emotional wellbeing by boosting serotonin production. This complex aids in filling vitamin deficiencies and enhancing overall health.
9
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
8
We investigated how a specific gene variation (MTHFR C677T) influences the outcome for patients with coronary heart disease and hypertension receiving folic acid and enalapril.
Over 540 patients were studied, dividing them into groups that received folic acid or standard treatment.
Our results revealed that patients who took folic acid had better outcomes, including lower rates of cardiovascular events, compared to those who did not. This indicates that folic acid supplementation may enhance treatment success for these high-risk patients.
Over 540 patients were studied, dividing them into groups that received folic acid or standard treatment.
Our results revealed that patients who took folic acid had better outcomes, including lower rates of cardiovascular events, compared to those who did not. This indicates that folic acid supplementation may enhance treatment success for these high-risk patients.
8
We explored the impact of long-term vitamin B1 (VB1) maintenance on heart failure (HF) outcomes through a study involving 88 patients. These patients were divided into three groups based on their VB1 levels: a control group with normal levels, a group receiving short-term supplementation, and a group focused on long-term maintenance of normal levels.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
References
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Song JW, Zhang ZS, Chen L, Wang QW, Xu JY, et al. Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model. J Nutr. 2024;154:3031. doi:10.1016/j.tjnut.2024.08.006
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. doi:10.1172/jci.insight.171005
- Morimoto J, Satogami K, Naraoka T, Taruya A, Tanaka A. Long-Term Maintenance of Normal Serum Vitamin B Levels Is Associated with Better Outcomes in Patients with Heart Failure. Int Heart J. 2024;65:458. doi:10.1536/ihj.23-550
